Internalization, phagolysosomal biogenesis and killing of mycobacteria in enucleated epithelial cells
نویسندگان
چکیده
منابع مشابه
Coxiella burnetii exhibits morphological change and delays phagolysosomal fusion after internalization by J774A.1 cells.
Coxiella burnetii, the etiological agent of Q fever, is an obligate intracellular bacterium proliferating within the harsh environment of the phagolysosome. Mechanisms controlling trafficking to, and survival of pathogens within, the phagolysosome are unknown. Two distinct morphological variants have been implicated as playing a role in C. burnetii survival. The dormant small-cell variant (SCV)...
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Antibiotics are typically more effective against replicating rather than nonreplicating bacteria. However, a major need in global health is to eradicate persistent or nonreplicating subpopulations of bacteria such as Mycobacterium tuberculosis (Mtb). Hence, identifying chemical inhibitors that selectively kill bacteria that are not replicating is of practical importance. To address this, we scr...
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Whereas amastigotes of the protozoan parasite Leishmania proliferate inside acidic phagolysosomal vacuoles of the macrophage, vacuoles induced by Leishmania donovani promastigotes during initiation of infection are poorly characterized. Here, evidence is presented that interaction of these parasitophorous vacuoles with endocytic organelles is very limited. In contrast, vacuoles formed around L....
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2011
ISSN: 1462-5814
DOI: 10.1111/j.1462-5822.2011.01615.x